Lowering serum uric acid to prevent acute kidney injury

被引：17
作者：
Ejaz, A. Ahsan [1 ]
Dass, Bhagwan [1 ]
Kambhampati, Ganesh [1 ]
Ejaz, Noel I. [2 ]
Maroz, Natallia [1 ]
Dhatt, Gurjit S. [1 ]
Arif, Amir A. [1 ]
Faldu, Chirag [1 ]
Lanaspa, Miguel A. [3 ]
Shah, Gaurav [1 ]
Johnson, Richard J. [3 ]
机构：
[1] Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA
[2] Coll Univ Chicago, Chicago, IL USA
[3] Univ Colorado, Hlth Sci Ctr, Div Renal Dis & Hypertens, Denver, CO USA
来源：
MEDICAL HYPOTHESES | 2012年 / 78卷 / 06期
关键词：
CARDIAC-SURGERY; GLOMERULAR HYPERTENSION; HYPERURICEMIA; COMPLICATION; MECHANISMS; DYNAMICS; CHILDREN; DISEASE; CELLS; RISK;
D O I：
10.1016/j.mehy.2012.03.011
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Epidemiological, experimental and clinical studies support a role for uric acid in acute kidney injury (AKI). We discuss how the conventional role of uric acid in AKI has now evolved from intratubular crystal deposition to pro-inflammatory, anti-angiogenic and immunological function. Data from recent studies are presented to support the hypothesis that uric acid may have a role in AKI via a crystal-independent process in addition to its traditionally accepted role to induce injury via crystal-dependent pathways. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：796 / 799
页数：4
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