Dose-dependent cholesterol-lowering effects of phytosterol/phytostanol-enriched margarine in statin users and statin non-users under free-living conditions

被引:18
作者
Eussen, Simone R. B. M. [1 ,2 ]
de Jong, Nynke [2 ]
Rompelberg, Cathy J. M. [2 ]
Garssen, Johan [1 ]
Verschuren, W. M. Monique [2 ]
Klungel, Olaf H. [1 ]
机构
[1] Utrecht Inst Pharmaceut Sci, NL-3508 TB Utrecht, Netherlands
[2] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands
关键词
Cholesterol; Phytosterols/phytostanols; Effectiveness; Statins; DENSITY-LIPOPROTEIN CHOLESTEROL; NON-HDL CHOLESTEROL; PLANT STANOL ESTER; STEROL-ESTER; CARDIOVASCULAR-DISEASE; CUSTOMARY USE; SERUM; THERAPY; RISK; METABOLISM;
D O I
10.1017/S1368980011000164
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: To assess the effectiveness (extent to which an intervention works in daily medical practice) of the use of phytosterol/phytostanol-enriched margarines to lower total and non-HDL cholesterol levels in users and non-users of statins. Design: Retrospective cohort study. Setting: Data were obtained from questionnaires on health and food intake from a population-based longitudinal cohort linked to pharmacy-dispensing records. Subjects: The analysis included 3829 men and women (aged 31-71 years) who were examined during 1998-2002 and re-examined at 5-year follow-up during 2003-2007. Results: Recommended doses of margarines were consumed by only 9% of the subjects. Serum total cholesterol decreased by respectively -0.16 (95% CI -0.26, -0.05) mmol/l, -1.40 (95% CI -1.51, -1.30) mmol/l and -1.64 (95% CI -1.91, -1.37) mmol/l in subjects who started to use phytosterols/phytostanols only, statins only or a combination of both compounds at some point in time between examination and re-examination, compared with subjects who did not start using phytosterols/phytostanols or statins. Cholesterol-lowering effects of the phytosterols/phytostanols were similar in statin users and statin non-users and increased with increasing intake of enriched margarine (no intake, 0; low intake, -0.017 (95% CI -0.16, 0.13) mmol/l; medium intake, -0.089 (95% CI -0.22, 0.038) mmol/l; high intake, -0.32 (95% CI -0.50, -0.14) mmol/l). Conclusions: Although recommended intake levels of the enriched margarines were not reached by all persons, these data show that under customary conditions of use phytosterols/phytostanols are effective in lowering cholesterol levels in both statin users and non-users.
引用
收藏
页码:1823 / 1832
页数:10
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