Cytotoxic diacetylenes from the stony coral Montipora species

被引：32

作者：

Alam, N

Bae, BH

Hong, JK

Lee, CO

Im, KS

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Korea Basic Sci Inst, Seoul, South Korea

[3] Korea Res Inst Chem Technol, Pharmaceut Screening Ctr, Taejon 305606, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 08期

关键词：

D O I：

10.1021/np010148b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new (1, 4-6, 9-14) and four known (2, 3, 7, 8) diacetylenes have been isolated from a brine shrimp active fraction of the methanolic extract of the stony coral Montipora sp. The structures were determined by combined spectroscopic methods. The compounds exhibited significant cytotoxicity against a small panel of human solid tumor cell lines. Montiporyne A (15), a previously reported congener, was also found to induce apoptosis in human colon tumor cell.

引用

页码：1059 / 1063

页数：5

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