Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia

被引：11
作者：
Li, Wenlan [1 ]
Swiderski, Kristy [1 ]
Murphy, Kate T. [1 ]
Lynch, Gordon S. [1 ]
机构：
[1] Univ Melbourne, Fac Med Dent & Hlth Sci, Sch Biomed Sci, Ctr Muscle Res,Dept Anat & Physiol, Melbourne, Vic 3010, Australia
来源：
ANTIOXIDANTS | 2022年 / 11卷 / 02期
关键词：
cancer; cachexia; plant extract; antioxidants; oxidative stress; skeletal muscle; inflammation; NF-KAPPA-B; SKELETAL-MUSCLE ATROPHY; TUMOR-NECROSIS-FACTOR; INDUCED OXIDATIVE STRESS; NATURAL-PRODUCT PRESENT; PROSTATE-CANCER; URSOLIC ACID; MOLECULAR TARGETS; MDX MICE; POMEGRANATE EXTRACT;
D O I：
10.3390/antiox11020183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer cachexia is the progressive muscle wasting and weakness experienced by many cancer patients. It can compromise the response to gold standard cancer therapies, impair functional capacity and reduce overall quality of life. Cancer cachexia accounts for nearly one-third of all cancer-related deaths and has no effective treatment. The pathogenesis of cancer cachexia and its progression is multifactorial and includes increased oxidative stress derived from both the tumor and the host immune response. Antioxidants have therapeutic potential to attenuate cancer-related muscle loss, with polyphenols, a group of plant-derived antioxidants, being the most widely investigated. This review describes the potential of these plant-derived antioxidants for treating cancer cachexia.
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页数：27
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