Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia

被引：11
作者：
Li, Wenlan [1 ]
Swiderski, Kristy [1 ]
Murphy, Kate T. [1 ]
Lynch, Gordon S. [1 ]
机构：
[1] Univ Melbourne, Fac Med Dent & Hlth Sci, Sch Biomed Sci, Ctr Muscle Res,Dept Anat & Physiol, Melbourne, Vic 3010, Australia
来源：
ANTIOXIDANTS | 2022年 / 11卷 / 02期
关键词：
cancer; cachexia; plant extract; antioxidants; oxidative stress; skeletal muscle; inflammation; NF-KAPPA-B; SKELETAL-MUSCLE ATROPHY; TUMOR-NECROSIS-FACTOR; INDUCED OXIDATIVE STRESS; NATURAL-PRODUCT PRESENT; PROSTATE-CANCER; URSOLIC ACID; MOLECULAR TARGETS; MDX MICE; POMEGRANATE EXTRACT;
D O I：
10.3390/antiox11020183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer cachexia is the progressive muscle wasting and weakness experienced by many cancer patients. It can compromise the response to gold standard cancer therapies, impair functional capacity and reduce overall quality of life. Cancer cachexia accounts for nearly one-third of all cancer-related deaths and has no effective treatment. The pathogenesis of cancer cachexia and its progression is multifactorial and includes increased oxidative stress derived from both the tumor and the host immune response. Antioxidants have therapeutic potential to attenuate cancer-related muscle loss, with polyphenols, a group of plant-derived antioxidants, being the most widely investigated. This review describes the potential of these plant-derived antioxidants for treating cancer cachexia.
引用
收藏
页数：27
相关论文
共 161 条
  • [1] Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
    Abrigo, Johanna
    Elorza, Alvaro A.
    Riedel, Claudia A.
    Vilos, Cristian
    Simon, Felipe
    Cabrera, Daniel
    Estrada, Lisbell
    Cabello-Verrugio, Claudio
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
  • [2] Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia
    Acharyya, S
    Butchbach, MER
    Sahenk, Z
    Wang, HT
    Saji, M
    Carathers, M
    Ringel, MD
    Skipworth, RJE
    Fearon, KCH
    Hollingsworth, MA
    Muscarella, P
    Burghes, AHM
    Rafael-Fortney, JA
    Guttridge, DC
    [J]. CANCER CELL, 2005, 8 (05) : 421 - 432
  • [3] Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome
    Acharyya, Swarnali
    Guttridge, Denis C.
    [J]. CLINICAL CANCER RESEARCH, 2007, 13 (05) : 1356 - 1361
  • [4] Cancer Chemoprevention by Pomegranate: Laboratory and Clinical Evidence
    Adhami, Vaqar Mustafa
    Khan, Naghma
    Mukhtar, Hasan
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2009, 61 (06): : 811 - 815
  • [5] A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury
    Akdemir, Fazile Nur Ekinci
    Gulcin, Ilhami
    Karagoz, Berna
    Soslu, Recep
    Alwasel, Saleh H.
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 : 114 - 118
  • [6] Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
    Al-Harbi, Sami A.
    Abdulrahman, Abdulrasheed O.
    Zamzami, Mazin A.
    Khan, Mohammad Imran
    [J]. FRONTIERS IN NUTRITION, 2021, 8
  • [7] Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3
    Alsamri, Halima
    El Hasasna, Hussain
    Al Dhaheri, Yusra
    Eid, Ali H.
    Attoub, Samir
    Iratni, Rabah
    [J]. FRONTIERS IN ONCOLOGY, 2019, 9
  • [8] Cancer cachexia, mechanism and treatment
    Aoyagi, Tomoyoshi
    Terracina, Krista P.
    Raza, Ali
    Matsubara, Hisahiro
    Takabe, Kazuaki
    [J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2015, 7 (04) : 17 - 29
  • [9] Molecular mechanisms involved in muscle wasting in cancer and ageing:: cachexia versus sarcopenia
    Argilés, JM
    Busquets, S
    Felipe, A
    López-Soriano, FJ
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (05) : 1084 - 1104
  • [10] The effect of ellagic acid on caspase-3/bcl-2/Nrf-2/NF-kB/TNF-α /COX-2 gene expression product apoptosis pathway: a new approach for muscle damage therapy
    Aslan, Abdullah
    Beyaz, Seda
    Gok, Ozlem
    Erman, Orhan
    [J]. MOLECULAR BIOLOGY REPORTS, 2020, 47 (04) : 2573 - 2582
12345678910