CARD9 as a potential therapeutic target in lung cancer

被引：0

作者：

Sheng, Ruanmei ^{[1
,2
]}

Yang, Zhiwen ^{[3
]}

机构：

[1] Shanghai Songjiang Dist Cent Hosp, Dept Emergency Med & Intens Care, Shanghai 201600, Peoples R China

[2] Nanjing Med Univ, Dept Emergency Med & Intens Care, Shanghai Songjiang Clin Med Coll, Shanghai 201600, Peoples R China

[3] Shanghai Songjiang Dist Cent Hosp, Dept Pharm, Shanghai 201600, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2021年 / 26卷 / 12期

关键词：

CARD9; Lung cancer; Clinical significance; Molecular mechanism; Therapy target; TUMOR-ASSOCIATED MACROPHAGES; SUPPRESSOR-CELLS; RECRUITMENT; ACTIVATION; OVEREXPRESSION; EXPRESSION; REGULATOR; PROTECTS; DECTIN-1; COLITIS;

D O I：

10.52586/5055]

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspase recruitment domain-containing protein 9 (CARD9) is highly expressed in myeloid cells and has been identified as a central regulator of innate immunity. In-creasingly, studies demonstrate that CARD9 also plays a critical role in the development of lung cancer. This review focuses on the clinical significance and potential molecular mechanisms that CARD9 plays in lung cancer.

引用

页码：1621 / 1626

页数：6

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