A novel and efficient synthesis of 2-substituted quinazolin-4(3H)-ones by the reaction of (het)arylmethanamines with isatoic anhydride

被引：15
作者：
Mahdavi, Mohammad [1 ]
Hassanzadeh, Rasool [2 ,3 ]
Soheilizad, Mehdi [2 ,3 ]
Golshani, Shiva [2 ,3 ]
Moghimi, Setareh [2 ,3 ]
Firoozpour, Loghman [1 ]
Shafiee, Abbas [2 ,3 ]
Foroumadi, Alireza [1 ,2 ,3 ]
机构：
[1] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran
[2] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran
[3] Univ Tehran Med Sci, Dept Med Chem, Pharmaceut Sci Res Ctr, Tehran, Iran
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 33期
基金：
美国国家科学基金会;
关键词：
Quinazoline; One-pot; Isatoic anhydride; Aerobic conditions; CuBr; ONE-POT SYNTHESIS; ANTIBACTERIAL; ACID; QUINAZOLINONES; CONSTITUENTS; DERIVATIVES; BIOACTIVITY; ALKALOIDS; AMINE;
D O I：
10.1016/j.tetlet.2016.07.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and straightforward method for the synthesis of quinazolin-4(3H)-ones is described. The one-pot reaction between isatoic anhydride and (het)arylmethanamines led to the formation of N-substituted anthranilamides, which under aerobic conditions in the presence of CuBr undergo an in situ oxidation-cyclization reaction to produce quinazolin-4(3H)-ones in good yields. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3770 / 3772
页数：3
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