Monodisperse Mesoporous Silica Nanoparticles: Synthesis and Application in Biomaterials

Monodisperse mesoporous silica nanoparticles are of promising applications in many current and emerging areas of technology because of their nature advantages. This review is devoted to the progress made in the last decade in synthesis and biomedical application of monodisperse mesoporous silica nanoparticles. We present a comprehensive overview of synthetic strategies for monodisperse mesoporous silica nanoparticles. These strategies are broadly categorized into three groups, such as dilute solution method, microemulsion method, and introduction of template/different additives to reaction system. Monodisperse mesoporous silica nanoparticles with good dispersion, different morphology and tuning pore sizes are successfully synthesized by means of the above-mentioned methods. Applications of monodisperse mesoporous silica nanoparticles in drug and large biomolecule delivery and controlled release, separation of the large biomolecule, biomarker and biomedical diagnosis are mostly described.