Serum pentraxin 3 levels are negatively associated with carotid intima media thickness in non-obese rheumatoid arthritis patients

Background: Pentraxin-3 (PTX3) is a long pentraxin that is supposed to participate in the inflammatory process and in atherosclerosis. Aim: To study PTX3 serum levels in rheumatoid arthritis (RA) patients to know if its serum levels may reflect disease activity and/or subclinical atherosclerosis. Methods: PTX3 and carotid intima media thickness (IMT) were studied in 85 RA patients (83.5% females, median age of 59 years old, median disease duration of 13 years) along with its demographic, clinical, serological and lipid profile. For comparison PTX3 was measured in 85 healthy volunteers. Results: PTX3 levels in RA patients were similar to controls (p = 0.21) and did not correlate with inflammatory activity measured by ESR (p = 0.39) CRP (p = 0.18) and DAS28 (p = 0.67). Serum PTX3 levels were higher in nonobese RA patients than in obese (BMI vs PTX3 with rho = -0.27; 95% IC = -0.46 to -0.06; p = 0.009). In non-obese patients, PTX3 correlated negatively with carotid IMT (rho = -0.40; 95% IC = -0.66 to -0.06; p = 0.01) but not in the obese ones (p = 0.26). In the obese RA patients therewas a negative correlation between PTX3 levels and LDL/HDL ratio (Rho = -0.29; 95% IC = -0.53-0.01; p = 0.03). Conclusions: PTX3 levels do not reflect inflammatory process in RA. However, it exerts a protective role in the process of atherogenesis in non-obese RA patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.