Fractal dimension of the choriocarcinoma cell invasion front

被引：7
作者：
Ahammer, H. [1 ]
Helige, Ch. [2 ]
Dohr, G. [2 ]
Weiss-Fuchs, U. [3 ]
Juch, H. [2 ]
机构：
[1] Med Univ Graz, Ctr Physiol Med, Inst Biophys, A-8010 Graz, Austria
[2] Med Univ Graz, Ctr Mol Med, Inst Cell Biol Hist & Embryol, A-8010 Graz, Austria
[3] ARC Seibersdorf Res GmbH, A-2444 Seibersdorf, Austria
来源：
PHYSICA D-NONLINEAR PHENOMENA | 2008年 / 237卷 / 04期
关键词：
Fractal dimension; invasion front; cancer; choriocarcinoma;
D O I：
10.1016/j.physd.2007.09.016
中图分类号：
O29 [应用数学];
学科分类号：
070104 ;
摘要：
The Minkowski dimension was calculated for the determination of the invasiveness of cancer cells, which were brought in close contact (confronted) to host tissues and cultivated in vitro. The confrontation cultures were histologically sectioned and stained immunohistochemically. Digital images of these sections were segmented, processed and the specimens' boundaries were investigated. The invasion front was treated as a fractal. The value of the Minkowski dimension increased with increased invasiveness of the cells. The Minkowski dimension could be used as a quantitative measure for cancer diagnosis. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：446 / 453
页数：8
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