Urokinase and tissue plasminogen activators and their inhibitor PAI-1 in human tumors

被引：27

作者：

Gershtein, ES ^{[1
]}

Kushlinskii, NE ^{[1
]}

机构：

[1] Russian Acad Med Sci, NN Blokhin Canc Res Ctr, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 01期

关键词：

urokinase plasminogen activator; tissue plasminogen activator; breast cancer; ovarian cancer; lung cancer;

D O I：

10.1023/A:1017542915662

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The content of urokinase and tissue plasminogen activators and their inhibitor PAI-1 in tumors and histologically intact tissues from patients with breast, ovarian, and non-small-cell lung cancer was measured by enzyme immunoassay. The content of urokinase plasminogen activator and PAI-1 was considerably increased in all malignant tumors, however the correlation between the expression of components of the plasminogen activation system and clinical morphological features and prognosis of the disease depends on the type of tumor.

引用

页码：67 / 72

页数：6

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