Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes

被引：54
作者：
Atheaya, Himanshu [1 ]
Khan, Shabana I. [2 ]
Mamgain, Ritu [1 ]
Rawat, Diwan S. [1 ]
机构：
[1] Univ Delhi, Dept Chem, Delhi 110007, India
[2] Univ Mississippi, Sch Pharm, Natl Ctr Nat Products Res, University, MS 38677 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期
关键词：
D O I：
10.1016/j.bmcl.2007.12.069
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H2O2/TFE in presence of MeReO3 as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry. (c) 2007 Elsevier Ltd. All rights reserved.
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页码：1446 / 1449
页数：4
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