Targeting Viral RNA-Dependent RNA Polymerases as an Antiviral Therapy

被引：2

作者：

Miranda Jr, Daniel ^{[1
]}

Sanchez, David Jesse ^{[1
]}

机构：

[1] Western Univ Hlth Sci, Dept Pharmaceut Sci, Coll Pharm, Pomona, CA 91766 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2021年 / 28卷 / 40期

关键词：

Antiviral; virus; remdesivir; ribavirin; favipiravir; SARS-CoV-2; COVID-19; CHRONIC HEPATITIS-C; RESPIRATORY SYNDROME; CRYSTAL-STRUCTURE; PLUS RIBAVIRIN; TOMATO LEAVES; EBOLA-VIRUS; IN-VITRO; SOFOSBUVIR; INFECTION; EFFICACY;

D O I：

10.2174/0929867328666210204205726

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Progressive globalization of our society brings not only worldwide integration, it also increases and promotes our exposure to new viral pathogens with evident impacts on our global health. Especially with the emergence of SARS-CoV-2, our biomedical re-search infrastructure has never been more compelled to rapidly develop antiviral regimens that demonstrate improved efficacy against these pathogens. Here, we showcase 3 poign-ant antivirals against the lucrative target, RNA-dependent RNA polymerase (RdRP) of RNA viruses - a timely and relevant topic given the present efforts against COVID-19. While effective drug designs against RdRP are important, their benefit and potential as a standard of care truly relies on them standing out in well-designed clinical trials.

引用

页码：8384 / 8391

页数：8

共 55 条

[1] Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection [J].

Afdhal, Nezam ;

Zeuzem, Stefan ;

Kwo, Paul ;

Chojkier, Mario ;

Gitlin, Norman ;

Puoti, Massimo ;

Romero-Gomez, Manuel ;

Zarski, Jean-Pierre ;

Agarwal, Kosh ;

Buggisch, Peter ;

Foster, Graham R. ;

Braeu, Norbert ;

Buti, Maria ;

Jacobson, Ira M. ;

Subramanian, G. Mani ;

Ding, Xiao ;

Mo, Hongmei ;

Yang, Jenny C. ;

Pang, Phillip S. ;

Symonds, William T. ;

McHutchison, John G. ;

Muir, Andrew J. ;

Mangia, Alessandra ;

Marcellin, Patrick .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (20) :1889-1898

[2] Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus [J].

Ago, H ;

Adachi, T ;

Yoshida, A ;

Yamamoto, M ;

Habuka, N ;

Yatsunami, K ;

Miyano, M .

STRUCTURE, 1999, 7 (11) :1417-1426

[3] Structural basis for RNA replication by the hepatitis C virus polymerase [J].

Appleby, Todd C. ;

Perry, Jason K. ;

Murakami, Eisuke ;

Barauskas, Ona ;

Feng, Joy ;

Cho, Aesop ;

Fox, David, III ;

Wetmore, Diana R. ;

McGrath, Mary E. ;

Ray, Adrian S. ;

Sofia, Michael J. ;

Swaminathan, S. ;

Edwards, Thomas E. .

SCIENCE, 2015, 347 (6223) :771-775

[4] Multifaceted action of Fuzeon as virus-cell membrane fusion inhibitor [J].

Ashkenazi, Avraham ;

Wexler-Cohen, Yael ;

Shai, Yechiel .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2011, 1808 (10) :2352-2358

[5] POLIOVIRUS-INDUCED RNA POLYMERASE AND EFFECTS OF VIRUS-SPECIFIC INHIBITORS ON ITS PRODUCTION [J].

BALTIMORE, D ;

FRANKLIN, RM ;

TAMM, I ;

EGGERS, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1963, 49 (06) :843-&

[6] PRELIMINARY DATA ON A VIRUS-SPECIFIC ENZYME SYSTEM RESPONSIBLE FOR SYNTHESIS OF VIRAL RNA [J].

BALTIMORE, D ;

FRANKLIN, RM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1962, 9 (05) :388-&

[7] Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus [J].

Behrens, SE ;

Tomei, L ;

DeFrancesco, R .

EMBO JOURNAL, 1996, 15 (01) :12-22

[8]

Beigel JH, 2020, NEW ENGL J MED, V383, P994, DOI 10.1056/NEJMc2022236

[9] Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection A Randomized Clinical Trial [J].

Borba, Mayla Gabriela Silva ;

Val, Fernando Fonseca Almeida ;

Sampaio, Vanderson Souza ;

Alexandre, Marcia Almeida Araujo ;

Melo, Gisely Cardoso ;

Brito, Marcelo ;

Mourao, Maria Paula Gomes ;

Brito-Sousa, Jose Diego ;

Baia-da-Silva, Djane ;

Guerra, Marcus Vinitius Farias ;

Hajjar, Ludhmila Abrahao ;

Pinto, Rosemary Costa ;

Balieiro, Antonio Alcirley Silva ;

Pacheco, Antonio Guilherme Fonseca ;

Santos, James Dean Oliveira, Jr. ;

Naveca, Felipe Gomes ;

Xavier, Mariana Simao ;

Siqueira, Andre Machado ;

Schwarzbold, Alexandre ;

Croda, Julio ;

Nogueira, Mauricio Lacerda ;

Romero, Gustavo Adolfo Sierra ;

Bassat, Quique ;

Fontes, Cor Jesus ;

Albuquerque, Bernardino Claudio ;

Daniel-Ribeiro, Claudio-Tadeu ;

Monteiro, Wuelton Marcelo ;

Lacerda, Marcus Vinicius Guimaraes .

JAMA NETWORK OPEN, 2020, 3 (04) :E208857

[10] A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 [J].

Boulware, David R. ;

Pullen, Matthew F. ;

Bangdiwala, Ananta S. ;

Pastick, Katelyn A. ;

Lofgren, Sarah M. ;

Okafor, Elizabeth C. ;

Skipper, Caleb P. ;

Nascene, Alanna A. ;

Nicol, Melanie R. ;

Abassi, Mahsa ;

Engen, Nicole W. ;

Cheng, Matthew P. ;

LaBar, Derek ;

Lother, Sylvain A. ;

MacKenzie, Lauren J. ;

Drobot, Glen ;

Marten, Nicole ;

Zarychanski, Ryan ;

Kelly, Lauren E. ;

Schwartz, Ilan S. ;

McDonald, Emily G. ;

Rajasingham, Radha ;

Lee, Todd C. ;

Hullsiek, Kathy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (06) :517-525

← 1 2 3 4 5 6 →