Mammary Lipid-Rich Carcinoma with Extensive Amyloid Deposition in a Dog

A 6-year-old female Labrador retriever presented with a mass in the right mammary gland, and swollen right inguinal and axillary lymph nodes. Fine needle aspiration biopsy suggested a malignant lipid-producing tumor, such as liposarcoma. Histopathologically, the neoplasms were solid, lobulated nests of atypical epithelial cells with a large amount of extracellular deposits of amyloid in both mammary gland and lymph nodes. The proliferating cells contained large cytoplasmic vacuoles, positive for oil red-O. These cells were immunopositivc for cytokeratin (AE1/AE3) and beta-casein and negative for SMA. The amyloid deposits were immunopositive for beta-casein. These findings suggested that the proliferating cells secreted beta-casein forming amyloid deposits. This is the first report of mammary lipid-rich carcinoma with extensive amyloid deposition derived from beta-casein.