Participation of low-threshold Ca2+ spike in the Purkinje cells complex spike

被引：14

作者：

Cavelier, Pauline ^{[1
]}

Lohof, Ann M. ^{[2
]}

Lonchamp, Etienne ^{[1
]}

Beekenkamp, Huguette ^{[1
]}

Mariani, Jean ^{[2
]}

Bossu, Jean-Louis ^{[1
]}

机构：

[1] Univ Strasbourg 1, CNRS, UMR7168,Inst Neurosci Cellulaires & Integrat, LC2,Dept Neurotransmiss & Secret Neuroendocrine, F-67084 Strasbourg, France

[2] Univ Paris 06, CNRS, UMR Neurobiol Proc Adaptatifs 7102, Paris 05, France

来源：

NEUROREPORT | 2008年 / 19卷 / 03期

关键词：

calcium spike; cerebellum; climbing fiber; complex spike; Purkinje cell; T-type and R-type calcium channels;

D O I：

10.1097/WNR.0b013e3282f4cb96

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Purkinje cells from cerebellar slice cultures, low-threshold Ca2+ spike (LTS) gives rise to complex bursts in the soma that resemble the complex spike induced by climbing fibers stimulation.We show that LTS is reduced by T-type and R-type Ca2+ channel blockers (SNX-482, nickel, or mibefradil).We propose that LTS is generated by openings of T-type Ca2+ channels (alpha-IG and/or alpha-II subunits) and R-type Ca2+ channels (alpha-IE subunit isoforms with a weak sensitivity to SNX-482 and to nickel). Using mibefradil we show that climbing fiber stimulation activates LTS, which contributes to the shape of the response. This Ca2+ entry may be involved in Ca2+ -dependent synaptic plasticity of the parallel fiber input induced by climbing fiber activation.

引用

页码：299 / 303

页数：5

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