Primary hepatoid adenocarcinoma of the uterine corpus: A case report with immunohistochemical study for expression of liver-enriched nuclear factors

被引：7

作者：

Ishibashi, Katsuhiko

Kishimoto, Takashi ^{[1
]}

Yonemori, Yoko ^{[2
]}

Hirashiki, Koichiro ^{[3
]}

Hiroshima, Kenzo ^{[4
]}

Nakatani, Yukio ^{[2
]}

机构：

[1] Chiba Univ, Dept Mol Pathol, Grad Sch Med, Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Dept Diagnost Pathol, Grad Sch Med, Chiba 2608670, Japan

[3] Chiba Univ, Dept Gynecol, Grad Sch Med, Chiba 2608670, Japan

[4] Dept Tokyo Womens Med Univ, Yachiyo Med Ctr, Tokyo, Japan

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2011年 / 207卷 / 05期

关键词：

Hepatoid adenocarcinoma; Uterus; AFP; Liver-enriched nuclear factors; Hepatocyte nuclear factor-4 alpha; ALPHA-FETOPROTEIN PRODUCTION; TRANSCRIPTION FACTORS; FACTOR-4-ALPHA; CARCINOMA; GENE; ENDOMETRIUM; TRANSDIFFERENTIATION; COMPONENT; STOMACH; CANCER;

D O I：

10.1016/j.prp.2011.02.010

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report a case of hepatoid adenocarcinoma of the uterus in an 86-year-old woman. Serum AFP was elevated (7824 ng/ml) on admission. The surgical specimen obtained by simple hysterectomy and bilateral salpingo-oophorectomy showed an exophytic tumor, 10.5 cm x 6.0 cm x 3.7 cm in size, in the uterine corpus. Microscopically, tumor cells proliferated in trabecular or cord-like arrangement, which was considered as "hepatoid appearance". An adenocarcinomatous component was intermingled. The expressions of liver-enriched transcription factors, hepatocyte nuclear factor (HNF)-1 beta, HNF-3, HNF-4 alpha, and CCAAT/enhancer binding protein (C/EBP)-beta, were investigated in the present case and in 19 cases of endometrioid adenocarcinoma (11 cases of Grade 2 and 8 cases of Grade 3), because these nuclear factors are involved in embryonal hepatogenesis. HNF-4 alpha was diffusely positive in the present case, but negative in all cases of endometrioid adenocarcinoma. HNF-3 and C/EBP-beta were positive for the present case and control adenocarcinoma cases (HNF-3, 36.8% and C/EBP-beta, 84.2%). HNF-1 beta was negative for both the present case and endometrioid adenocarcinomas. This is the first report to demonstrate HNF-4 alpha expression in this rare uterine tumor. (c) 2011 Elsevier GmbH. All rights reserved.

引用

页码：332 / 336

页数：5

共 24 条

[1] An α-fetoprotein-producing hepatoid adenocarcinoma of the endometrium [J].