The clinical study of serum hs-CRP, TNF-α, PCT and IL-6 in patients with acute exacerbation of chronic obstructive pulmonary disease

To investigate the serum levels of hs-CRP, PCT, IL-6 and TNF-alpha in patient with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and their relationship with gas analysis test and COPD assessment test (CAT). 80 cases of AECOPD patients were collected in experimental group, and another 80 cases of COPD patients in stable stage was treated as control group. Then, serum levels of hs-CRP, PCT, IL-6 and TNF-alpha, gas analysis test in artery and CAT scores were measured in the two groups. Results showed that serum levels of hs-CRP, PCT, IL-6 and TNF-alpha, PaCO2 and CAT scores of patients in experimental group were significantly elevated compared with that of control group (P<0.0001). For experimental group, levels of hs-CRP, PCT, IL-6 and TNF-alpha, PaCO2 and CAT in prior treatment patients were higher than that of post-treatment patients (P<0.0001). PaO2 of pre-treatment patients were lower than that of control patients. Furthermore, PaO2 levels could be significantly increased by treatment compared with that of pre-treatment patients (P<0.0001). Levels of hs-CRP, PCT, IL-6 and TNF-alpha were positively correlated with PaCO2 and CAT score, the difference was statistically significant, and they have negative correlation with the level of PaO2, the difference was statistically significant. The measure of hs-CRP, PCT, IL-6 and TNF-alpha combined with CAT score and gas analysis test may be a good assessment and disease monitoring in AECOPD.