Cellular life span and the Warburg effect

被引：87

作者：

Kondoh, Hiroshi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Sakyo Ku, Kyoto 6068507, Japan

来源：

EXPERIMENTAL CELL RESEARCH | 2008年 / 314卷 / 09期

关键词：

phosphoglycerate mutase; glycolysis; immortalization; p53; the Warburg effect; ROS; hypoxia;

D O I：

10.1016/j.yexcr.2008.03.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo. Enhanced glycolysis is essential both in the step of immortalization and transformation, as it renders cells resistant to oxidative stress and adaptive to hypoxic condition, respectively. ES, immortalized primary, and cancerous cells display the common concerted metabolic shift, including enhanced glycolysis with reduced mitochondrial respiration by poorly characterized mechanism. Discovery of a novel regulatory mechanism for such a metabolic shift might be essential for the future development of cancer diagnosis and anti-cancer therapy. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1923 / 1928

页数：6

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