Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China

被引：29

作者：

Chen, S. -P. ^{[1
]}

Yu, M. ^{[1
]}

Jiang, T. ^{[1
]}

Deng, Y. -Q. ^{[1
]}

Qin, C. -F. ^{[1
]}

Han, J. -F. ^{[1
]}

Qin, E. -D. ^{[1
]}

机构：

[1] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2008年 / 153卷 / 06期

关键词：

D O I：

10.1007/s00705-008-0090-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively. The recombinant dengue virus was further confirmed by phylogenetic analysis based on its recombination and non-recombination regions. This appears to be the first study to confirm the existence of three recombination regions in a single dengue virus isolate and to report recombination between parent virus strains isolated from the same geographic area (Guangdong province, China). It is also the first to report breakpoints within the NS3 gene of dengue viruses.

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页码：1175 / 1179

页数：5

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