Inflammatory myofibroblastic tumor arising from soft tissues of extremities harboring a novel CLIP2-ALK fusion

被引：3

作者：

Ding, Ru ^{[1
]}

Li, Xiao ^{[1
]}

Zhu, Xiao-Mei ^{[1
]}

Song, Quo-Xing ^{[1
]}

Fan, Qin-He ^{[1
]}

Zhang, Zhi-Hong ^{[1
]}

Gong, Qi-Xing ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Pathol, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China

来源：

PATHOLOGY INTERNATIONAL | 2020年 / 70卷 / 10期

关键词：

ALK; CLIP2; inflammatory myofibroblastic tumor; somatic soft tissue; ANAPLASTIC LYMPHOMA-KINASE; RET GENE FUSIONS; ALK; REARRANGEMENTS; PSEUDOTUMOR; ROS1;

D O I：

10.1111/pin.12988

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 34-year-old Chinese woman found a lump in her left leg for more than 3 weeks without any discomfort. Grossly, the tumor was relatively well delineated with focal infiltration. Histopathologic evaluation showed a compact fascicular spindle cell proliferation with variable myxoid and collagenous stroma and scattered inflammatory infiltrate. Immunohistochemically, the tumor cells showed positive expression of ALKD5F3 and SMA and negative expression of CD34, desmin, and cytokeretin. Fluorescence in situ hybridization analysis of the ALK locus showed break-apart signals in 20% of tumor cells, and DNA sequencing discovered a novel CLIP2-ALK fusion gene. The lesion was diagnosed as an inflammatory myofibroblastic tumor (IMT). To the best of our knowledge, this is the first case with CLIP2-ALK gene fusion in the somatic soft tissue IMTs.

引用

页码：798 / 803

页数：6

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