Mild cognitive impairment in Parkinson's disease

被引:2
作者
Goldman, J. G. [1 ]
Litvan, I. [2 ]
机构
[1] Rush Univ, Dept Neurol Sci, Sect Parkinson Dis & Movement Disorders, Chicago, IL 60612 USA
[2] Univ Calif San Diego, Dept Neurosci, Movement Disorder Program, San Diego, CA 92103 USA
关键词
Parkinson disease; Dementia; Psychomotor disorders; Alzheimer disease; DEMENTIA RATING-SCALE; CSF AMYLOID-BETA; NEUROPSYCHIATRIC SYMPTOMS; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; WORKING-MEMORY; DEFICITS; INCIDENT; DYSFUNCTION; ASSOCIATION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Parkinson's disease (PD) traditionally has been defined by its characteristic motor hallmarks, but non-motor features such as cognitive impairment and dementia are increasingly recognized as part of PD. Mild cognitive impairment (MCI) is common in non-demented PD patients, occurring in about 20-50%. Frequency estimates and clinical features of mild cognitive impairment in PD (PD-MCI), however, vary across studies due to methodological differences and lack of uniform diagnostic criteria for PD-MCI. Overall, PD-MCI patients exhibit nonamnestic deficits in cognitive domains such as executive function, attention, and visuospatial function; however, the cognitive phenotype of PD-MCI is heterogeneous with some patients demonstrating greater amnestic deficits. PD-MCI patients, particularly those with posterior cortical profiles, may be at high risk for developing dementia. Various biomarkers studied in PD-MCI including cerebrospinal fluid, genetic analyses, and neuroimaging suggest that there may be distinct PD-MCI profiles. Future studies using uniform PD-MCI diagnostic criteria and incorporating biomarkers and longitudinal follow-up of PD-MCI cohorts are needed to understand PD-MCI as a transitional state between normal cognition and dementia.
引用
收藏
页码:441 / 459
页数:19
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