Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles

被引：12
|
作者：
Du, Haiying [1 ]
Dudognon, Yohan [1 ]
Duque, Maria del Mar Sanchez [1 ]
Goudedranche, Sebastien [1 ]
Bonne, Damien [1 ]
Rodriguez, Jean [1 ]
Bugaut, Xavier [1 ]
Constantieux, Thierry [1 ]
机构：
[1] Aix Marseille Univ, CNRS, Cent Marseille, ISm2, Marseille, France
来源：
SYNTHESIS-STUTTGART | 2016年 / 48卷 / 20期
关键词：
1,3-dicarbonyls; enantioselectivity; heterocycles; Michael addition; multicomponent reactions; organocatalysis; ASYMMETRIC MICHAEL REACTION; HIGHLY EFFICIENT ACCESS; BETA-KETOAMIDES; CASCADE REACTIONS; DOMINO REACTION; NITROOLEFINS; CONSTRUCTION; AMIDES; DERIVATIVES; CYCLIZATION;
D O I：
10.1055/s-0035-1561490
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this feature article, a general perspective of the research program aimed towards the preparation of polycyclic heterocycles by the means of enantioselective organocatalytic multicomponent reactions is presented. Guidelines for reaction design, including the selection of substrates and organocatalysts are discussed. For all transformations, scope and limitations are presented, along with post-functionalization to afford diversified heterocyclic scaffolds. 1 Introduction 2 Type I Products: 1,4,5,6-Tetrahydropyridines 3 Type II Products: 1,2,3,4-Tetrahydropyridines 4 Type III Products: Bridged Perhydropyridines 5 Conclusion and Perspective
引用
收藏
页码：3479 / 3503
页数：25
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