Diet-induced hypercholesterolemia impaired testicular steroidogenesis in mice through the renin-angiotensin system

被引：19

作者：

Martinez-Martos, Jose M. ^{[1
]}

Arrazola, Marce ^{[1
]}

Mayas, Maria D. ^{[1
]}

Carrera-Gonzalez, Maria P. ^{[1
]}

Garcia, Maria J. ^{[1
]}

Ramirez-Exposito, Maria J. ^{[1
]}

机构：

[1] Univ Jaen, Dept Hlth Sci, Unit Physiol, Expt & Clin Physiopathol Res Grp BIO0296,Fac Expt, E-23071 Jaen, Spain

来源：

GENERAL AND COMPARATIVE ENDOCRINOLOGY | 2011年 / 173卷 / 01期

关键词：

Hypercholesterolemia; Steroidogenesis; Testicular renin-angiotensin system; Aminopeptidase A; Aminopeptidase B; Aminopeptidase N; Testosterone; AMINOPEPTIDASE; TESTOSTERONE; ATHEROSCLEROSIS; RELEASE; CLONING; TESTIS; CELLS;

D O I：

10.1016/j.ygcen.2011.04.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypercholesterolemia and low testosterone concentrations in men are associated with a high risk factor for atherosclerosis. It is known that cholesterol serves as the major precursor for the synthesis of the sex hormones. The bioactive peptides of the renin-angiotensin-system localized in the gonads play a key role in the relation between cholesterol and testosterone by modulating steroidogenesis and inhibiting testosterone production. In the present work, we evaluated the effects of diet-induced hypercholesterolemia on circulating testosterone levels and its relationship with the testicular RAS-regulating specific aminopeptidase activities in male mouse. A significant decrease in serum circulating levels of testosterone was observed after induced hypercholesterolemia. The changes found in aminopeptidase activities suggest a role of Ang III and Ang IV in the regulation of steroidogenesis. (C) 2011 Published by Elsevier Inc.

引用

页码：15 / 19

页数：5

共 24 条

[1] Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase [J].