Bone marrow stromal cells generate muscle cells and repair muscle degeneration

被引：451

作者：

Dezawa, M ^{[1
]}

Ishikawa, H

Itokazu, Y

Yoshihara, T

Hoshino, M

Takeda, S

Ide, C

Nabeshima, Y

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Anat & Neurobiol, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Sakyo Ku, Kyoto 6068501, Japan

[3] Natl Ctr Neurol & Psychiat, Dept Mol Therapy, Tokyo 1878502, Japan

来源：

SCIENCE | 2005年 / 309卷 / 5732期

关键词：

D O I：

10.1126/science.1110364

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.

引用

页码：314 / 317

页数：4

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