Photophysical and biological investigation of novel luminescent Ru(II)-polypyridyl-1,8-naphthalimide Troger's bases as cellular imaging agents

被引：72

作者：

Elmes, Robert B. P. ^{[2
,3
]}

Erby, Marialuisa ^{[1
,3
]}

Bright, Sandra A. ^{[1
,3
]}

Williams, D. Clive ^{[1
,3
]}

Gunnlaugsson, Thorfinnur ^{[2
,3
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

[3] Univ Dublin Trinity Coll, Inst Biomed Sci, Dublin 2, Ireland

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 20期

基金：

爱尔兰科学基金会;

关键词：

DNA-BINDING; RECOGNITION; COMPLEXES; DERIVATIVES; CHEMISTRY; SCAFFOLDS; EMISSION; LIGANDS; ANALOGS; CLEFTS;

D O I：

10.1039/c2cc17274g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and photophysical properties of 1 and 2, two Ru(II)-polypyridyl based-1,8-naphthalimide Troger's bases, are described; these were found to stabilize double stranded DNA, undergo rapid cellular uptake, displaying good luminescence without affecting cell viability even after 24 hours of incubation.

引用

收藏

页码：2588 / 2590

页数：3

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