Severity of polymicrobial sepsis modulates mitochondrial function in rat liver

被引：10

作者：

Herminghaus, A. ^{[1
]}

Barthel, F. ^{[1
]}

Heinen, A. ^{[2
]}

Beck, C. ^{[1
]}

Vollmer, C. ^{[1
]}

Bauer, I. ^{[1
]}

Weidinger, A. ^{[3
]}

Kozlov, A. V. ^{[3
]}

Picker, O. ^{[1
]}

机构：

[1] Univ Hosp Duesseldorf, Dept Anesthesiol, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Inst Cardiovasc Physiol, D-40225 Dusseldorf, Germany

[3] Ludwig Boltzmann Inst Expt & Clin Traumatol, A-1200 Vienna, Austria

来源：

MITOCHONDRION | 2015年 / 24卷

关键词：

Mitochondrial function; Respirometry; Sepsis; Colon ascendens stent peritonitis; OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM; DYSFUNCTION; MODEL; HEPATOCYTES; OXYGENATION; THERAPY; COLON;

D O I：

10.1016/j.mito.2015.08.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial dysfunction is assumed to be an important contributor to multi organ dysfunction syndrome. Here, the effects of varying degrees of sepsis on hepatic mitochondrial function were investigated. Moderate or more severe sepsis was induced in rats using a colon ascendens stent peritonitis (CASP)-model (16 G and 14 G stent respectively). Respiratory control ratio (RCR) was significantly higher in the 16 G-group and unchanged in the 14 G-group compared with healthy controls. The ADP/O ratio was similar in all groups. Our results indicate that different severities of sepsis differently influence the mitochondrial function, which could be a sign of adaptive reaction. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：122 / 128

页数：7

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