Effect of crude fractions of Psoralea corylifolia seed extract on bone calcification

被引：58

作者：

Miura, H

Nishida, H

Linuma, M

机构：

[1] GIFU PHARMACEUT UNIV,DEPT PHARMACOGNOSY,GIFU 502,JAPAN

[2] GIFU PHARMACEUT UNIV,LAB HLTH & PHYS EDUC,GIFU 502,JAPAN

[3] MARUHO CO LTD,HIKONE RES LABS,HIKONE,SHIGA 52202,JAPAN

来源：

PLANTA MEDICA | 1996年 / 62卷 / 02期

关键词：

Psoralea corylifolia; Leguminosae; bone calcification; inorganic phosphorus; rachitis;

D O I：

10.1055/s-2006-957839

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Non-polar crude fractions (Ho-0 and Ho-1) of an acetone extract of Psoralea corylifolia seeds were administrated orally to untreated and experimental rachitic rats. In the biological screening of the fractions, Ho-1, an elution with n-hexane-ethyl acetate by column chromatography over silica gel of the acetone extract, untreated rats showed a significant elevation of the serum inorganic phosphorus and revealed histomorphometrically a significant increase in bone calcification. When Ho-0, an elution with n-hexane, and Ho-1 were administrated to the rachitic rats fed with a vitamin D-free, low-phosphorus diet, they not only increased significantly the concentration of inorganic phosphorus in serum, but also significantly promoted bone calcification. Administration of 30 mg/kg of Ho-1 resulted in a marked decrease of osteoid volume and improvement of hyperosteoidosis in rachitic rats. These results suggested that Ho-0 and Ho-1 are useful as a remedy for bone fracture, osteomalacia, osteoporosis, and related conditions.

引用

页码：150 / 153

页数：4

共 17 条

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