Application of surface enhanced Raman scattering to the solution based detection of a popular legal high, 5,6-methylenedioxy-2-aminoindane (MDAI)

被引：30

作者：

Mabbott, Samuel ^{[1
,2
]}

Alharbi, Omar ^{[1
]}

Groves, Kate ^{[1
]}

Goodacre, Royston ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs, England

[2] Univ Strathclyde, Dept Pure & Appl Chem, Ctr Mol Nanometrol, Glasgow G1 1XL, Lanark, Scotland

来源：

ANALYST | 2015年 / 140卷 / 13期

基金：

英国生物技术与生命科学研究理事会;

关键词：

DESIGNER DRUGS;

D O I：

10.1039/c5an00591d

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The ever increasing numbers and users of designer drugs means that analytical techniques have to evolve constantly to facilitate their identification and detection. We report that surface enhanced Raman scattering (SERS) offers a relatively fast and inexpensive method for the detection of MDAI at low concentrations. Careful optimisation of the silver sol, and salt concentrations was undertaken to ensure the SERS analysis was both reproducible and sensitive. The optimised system demonstrated acceptable peak variations of less than 15% RSD and resulted in a detection limit of just 8 ppm (5.4 x 10(-5) M).

引用

页码：4399 / 4406

页数：8

共 17 条

[1] Reference materials for new psychoactive substances [J].

Archer, Roland P. ;

Treble, Ric ;

Williams, Keith .

DRUG TESTING AND ANALYSIS, 2011, 3 (7-8) :505-514

[2]

Casale J.F., 2012, MICROGRAM J, V9, P33

[3]

Department of Health: Isle of Man, ISL MAN BANS SO CALL

[4] Microcrystalline identification of selected designer drugs [J].

Elie, Leonie ;

Baron, Mark ;

Croxton, Ruth ;

Elie, Mathieu .

FORENSIC SCIENCE INTERNATIONAL, 2012, 214 (1-3) :182-188

[5] 5,6-Methylenedioxy-2-aminoindane: from laboratory curiosity to legal high' [J].

Gallagher, Cathal T. ;

Assi, Sulaf ;

Stair, Jacqueline L. ;

Fergus, Suzanne ;

Corazza, Ornella ;

Corkery, John M. ;

Schifano, Fabrizio .

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2012, 27 (02) :106-112

[6]

Johnson M. P., 1991, EUR J PHARMACOL, V23, P9

[7] Surface enhanced Raman scattering enhancement factors: a comprehensive study [J].

Le Ru, E. C. ;

Blackie, E. ;

Meyer, M. ;

Etchegoin, P. G. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (37) :13794-13803

[8] ADSORPTION AND SURFACE-ENHANCED RAMAN OF DYES ON SILVER AND GOLD SOLS [J].

LEE, PC ;

MEISEL, D .

JOURNAL OF PHYSICAL CHEMISTRY, 1982, 86 (17) :3391-3395

[9] Optimization of Parameters for the Quantitative Surface-Enhanced Raman Scattering Detection of Mephedrone Using a Fractional Factorial Design and a Portable Raman Spectrometer [J].

Mabbott, Samuel ;

Correa, Elon ;

Cowcher, David P. ;

Allwood, J. William ;

Goodacre, Royston .

ANALYTICAL CHEMISTRY, 2013, 85 (02) :923-931

[10] 2p or not 2p: tuppence-based SERS for the detection of illicit materials [J].

Mabbott, Samuel ;

Eckmann, Alex ;

Casiraghi, Cinzia ;

Goodacre, Royston .

ANALYST, 2013, 138 (01) :118-122

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