Primary cardiac rhabdomyosarcoma successfully treated with eribulin: a case report

被引:6
作者
Ota, Shinichiro [1 ,2 ,3 ,4 ]
Shimonaga, Takashi [2 ,5 ]
Yuki, Shintaro [2 ,6 ]
Kuraoka, Kazuya [2 ,7 ]
Ogawa, Toshiya [4 ]
Hirata, Taizo [1 ,2 ]
机构
[1] Natl Hosp Org Kure Med Ctr, Dept Med Oncol, 3-1 Aoyama Cho, Kure, Hiroshima 7370023, Japan
[2] Chugoku Canc Ctr, 3-1 Aoyama Cho, Kure, Hiroshima 7370023, Japan
[3] Japan Maritime Self Def Force, Serv Sch 1, Etajima, Japan
[4] Japan Self Def Force Hosp Kure, Kure, Hiroshima, Japan
[5] Natl Hosp Org Kure Med Ctr, Dept Cardiol, Kure, Hiroshima, Japan
[6] Natl Hosp Org Kure Med Ctr, Dept Radiat Oncol, Kure, Hiroshima, Japan
[7] Natl Hosp Org Kure Med Ctr, Dept Pathol, Kure, Hiroshima, Japan
关键词
embryonal rhabdomyosarcoma; eribulin; soft tissue sarcomas; SOFT-TISSUE; PEDIATRIC RHABDOMYOSARCOMA; SARCOMA; ADULT; CLASSIFICATION; CHEMOTHERAPY; THERAPY; TUMORS;
D O I
10.1097/CAD.0000000000000860
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Rhabdomyosarcoma is the most common soft tissue sarcoma that typically occurs in children and adolescents and is rare in adults. Furthermore, as cardiac tumor is rare, adult cardiac rhabdomyosarcoma is a very rare entity. Here, we report the case of a 68-year-old woman with cardiac rhabdomyosarcoma who was successfully treated with eribulin. She presented with sudden loss of consciousness, which was attributed to the cardiac tumor. The tumor was resected by emergency surgery and was diagnosed as embryonal rhabdomyosarcoma. Although surgical treatment alleviated her symptoms, the residual tumor increased in size after surgery and required multimodal treatment. First-line chemotherapy with the vincristine, actinomycin D, and cyclophosphamide regimen had to be discontinued owing to adverse events, and thus eribulin was used as a second-line treatment. Eribulin was better tolerated and helped maintain a stable disease status for >18 months. This reported case of cardiac rhabdomyosarcoma is the first case to be successfully treated with eribulin over a relatively long period. Eribulin therapy may thus be a viable treatment alternative for rhabdomyosarcoma.
引用
收藏
页码:304 / 309
页数:6
相关论文
共 28 条
  • [1] Vincristine, Actinomycin, and Cyclophosphamide Compared With Vincristine, Actinomycin, and Cyclophosphamide Alternating With Vincristine, Topotecan, and Cyclophosphamide for Intermediate-Risk Rhabdomyosarcoma: Children's Oncology Group Study D9803
    Arndt, Carola A. S.
    Stoner, Julie A.
    Hawkins, Douglas S.
    Rodeberg, David A.
    Hayes-Jordan, Andrea A.
    Paidas, Charles N.
    Parham, David M.
    Teot, Lisa A.
    Wharam, Moody D.
    Breneman, John C.
    Donaldson, Sarah S.
    Anderson, James R.
    Meyer, William H.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (31) : 5182 - 5188
  • [2] CHEN HZ, 1992, CHINESE MED J-PEKING, V105, P153
  • [3] Sarcoma Classification: An Update Based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone
    Doyle, Leona A.
    [J]. CANCER, 2014, 120 (12) : 1763 - 1774
  • [4] Rhabdomyosarcoma in adolescent and young adult patients: current perspectives
    Egas-Bejar, Daniela
    Huh, Winston W.
    [J]. ADOLESCENT HEALTH MEDICINE AND THERAPEUTICS, 2014, 5 : 115 - 125
  • [5] Response to chemotherapy and predictors of survival in adult rhabdomyosarcoma
    Esnaola, NF
    Rubin, BP
    Baldini, EH
    Vasudevan, N
    Demetri, GD
    Fletcher, CDM
    Singer, S
    [J]. ANNALS OF SURGERY, 2001, 234 (02) : 215 - 223
  • [6] Rhabdomyosarcoma in adults - A retrospective analysis of 171 patients treated at a single institution
    Ferrari, A
    Dileo, P
    Casanova, M
    Bertulli, R
    Meazza, C
    Gandola, L
    Navarria, P
    Collini, P
    Gronchi, A
    Olmi, P
    Fossati-Bellani, F
    Casali, PG
    [J]. CANCER, 2003, 98 (03) : 571 - 580
  • [7] Rhabdomyosarcoma and Extraosseous Ewing Sarcoma
    Gurria, Juan P.
    Dasgupta, Roshni
    [J]. CHILDREN-BASEL, 2018, 5 (12):
  • [8] Rhabdomyosarcoma of the head and neck in children
    Hicks, J
    Flaitz, C
    [J]. ORAL ONCOLOGY, 2002, 38 (05) : 450 - 459
  • [9] A case of heavily pretreated metastatic cardiac angiosarcoma treated successfully using eribulin
    Inagaki, Chiaki
    Shimoi, Tatsunori
    Okuma, Hitomi
    Kitano, Akiko
    Shimomura, Akihiko
    Noguchi, Emi
    Kodaira, Makoto
    Yunokawa, Mayu
    Yonemori, Kan
    Shimizu, Chikako
    Yoshida, Akihiko
    Fujiwara, Yasuhiro
    Tamura, Kenji
    [J]. ANTI-CANCER DRUGS, 2018, 29 (01) : 97 - 101
  • [10] Postoperative nomogram for 12-year sarcoma-specific death
    Kattan, MW
    Leung, DHY
    Brennan, MF
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (03) : 791 - 796