Spontaneous oscillations of dressed neurons: A new mechanism for epilepsy?

被引：94

作者：

Nadkarni, S ^{[1
]}

Jung, P

机构：

[1] Ohio Univ, Dept Phys & Astron, Athens, OH 45701 USA

[2] Ohio Univ, Quantitat Biol Inst, Athens, OH 45701 USA

来源：

PHYSICAL REVIEW LETTERS | 2003年 / 91卷 / 26期

关键词：

D O I：

10.1103/PhysRevLett.91.268101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Most modeling studies of neurons and neuronal networks are based on the assumption that the neurons are isolated from their normal environment. Based on recent experimental data we put forward a model for neurons that incorporates the influence of the surrounding glia (dressed neurons). We predict seizurelike spontaneous oscillations in the absence of stimuli for strong coupling between neurons and astrocytes. Consistent with our predictions, a signature of this enhanced crosstalk, over expression of glutamate receptors in astrocytes, has been observed specifically in epileptic tissue.

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