Enantioselective synthesis of 2,3-disubstituted piperidines from (S)-methylpyroglutamate

被引：37

作者：

Calvez, O ^{[1
]}

Chiaroni, A ^{[1
]}

Langlois, N ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(98)02190-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-methoxy-N-methylamide derived from (S)-methylpyroglutamate was prepared in good yield and allowed the addition of Grignard reagents. Erythro (2S)-1 -benzyl-2-hydroxybenzyl pyrrolidine obtained by this way was converted into (2S,3R)-1-benzyl-3-hydroxy-2-phenylpiperidine and its chloro analog. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：9447 / 9450

页数：4

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