Changes of Synaptic Plasticity in Multiple Sclerosis

被引：5

作者：

Yuan, Ti-Fei ^{[1
]}

Shan, Chunlei ^{[2
]}

Arias-Carrion, Oscar ^{[3
]}

机构：

[1] Nanjing Normal Univ, Sch Psychol, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Rehabil Med, Nanjing, Peoples R China

[3] Hosp Gen Dr Manuel Gea Gonzalez, Mexico City, DF, Mexico

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2015年 / 14卷 / 02期

关键词：

Experimental autoimmune encephalomyelitis; inflammation; multiple sclerosis; N-methyl-D-aspartic acid; synaptic plasticity; trophic factor; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL MOTOR PLASTICITY; LONG-TERM POTENTIATION; TRANSMISSION; REORGANIZATION; INFLAMMATION; STIMULATION; PROGRESSION; DISABILITY; DISEASE;

D O I：

10.2174/1871527313666141114203620

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Patients with multiple sclerosis ( MS) often suffer from cognitive dysfunction; the underlying mechanisms have not been fully elucidated. Recent studies suggest that MS leads to heightened synaptic transmission and plasticity in different brain areas, and therefore may contribute to the observed behavioral abnormalities. Recent findings demonstrate synaptic plasticity changes in MS, including evidence from animal models of experimental autoimmune encephalomyelitis and human MS patients.

引用

页码：152 / 154

页数：3

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