Antioxidative effect of sesamol and related compounds on lipid peroxidation

被引：0
|
作者：
Uchida, M [1 ]
Nakajin, S [1 ]
Toyoshima, S [1 ]
Shinoda, M [1 ]
机构：
[1] HOSHI UNIV, FAC PHARMACEUT SCI, DEPT BIOCHEM, SHINAGAWA KU, TOKYO 142, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1996年 / 19卷 / 04期
关键词：
lipid peroxidation; antioxidative effect; sesamol; methylenedioxy-phenyl compound;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of sesamol and 20 related compounds on the lipid peroxidation of liposomes induced by Fe2+, on the lipid peroxidation of rat liver microsomes induced by CCl4 or NADPH and on the lipid peroxidation of mitochondria induced by ascorbate/Fe2+ were demonstrated. Consequently, sesamol and related compounds, such as 3-methoxy-4-hydroxyquinone, isosafrol, isoeugenol, eugenol, 3,4-methylenedioxyaniline, catechol, hydroxy-hydroquinone, 3,4-dimethoxyaniline and caffeic acid, exhibited powerful inhibitory effects on the lipid peroxidation system investigated. In particular, isoeugenol was the most powerful inhibitor among all the sesamol-related compounds tested on the lipid peroxidation system. In addition, 1,2-methylenedioxybenzene, ferulic acid, and 3,4-methylenedioxynitrobenzene were also effective on the lipid peroxidation system of liposomes induced by Fe2+. The correlation between the structures of sesamol-related compounds and their inhibitory effect is discussed.
引用
收藏
页码：623 / 626
页数：4
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