The genome of Nanoarchaeum equitans:: Insights into early archaeal evolution and derived parasitism

被引：356

作者：

Waters, E ^{[1
]}

Hohn, MJ

Ahel, I

Graham, DE

Adams, MD

Barnstead, M

Beeson, KY

Bibbs, L

Bolanos, R

Keller, M

Kretz, K

Lin, XY

Mathur, E

Ni, JW

Podar, M

Richardson, T

Sutton, GG

Simon, M

Söll, D

Stetter, KO

Short, JM

Noordewier, M

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[2] Diversa Corp, San Diego, CA 92121 USA

[3] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

[4] Univ Regensburg, Lehrstuhl Mikrobiol & Archaeenzentrum, D-93053 Regensburg, Germany

[5] Celera Genom Rockville, Rockville, MD 20850 USA

[6] Yale Univ, Dept Mol Biophys, New Haven, CT 06520 USA

[7] Yale Univ, Dept Biochem, New Haven, CT 06520 USA

[8] Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 22期

关键词：

D O I：

10.1073/pnas.1735403100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hyperthermophile Nanoarchaeum equitans is an obligate symbiont growing in coculture with the crenarchaeon Ignicoccus. Ribosomal protein and rRNA-based phylogenies place its branching point early in the archaeal lineage, representing the new archaeal kingdom Nanoarchaeota. The N. equitans genome (490,885 base pairs) encodes the machinery for information processing and repair, but lacks genes for lipid, cofactor, amino acid, or nucleotide biosyntheses. It is the smallest microbial genome sequenced to date, and also one of the most compact, with 95% of the DNA predicted to encode proteins or stable RNAs. Its limited biosynthetic and catabolic capacity indicates that N. equitans' symbiotic relationship to Ignicoccus is parasitic, making it the only known archaeal parasite. Unlike the small genomes of bacterial parasites that are undergoing reductive evolution, N. equitans has few pseudogenes or extensive regions of noncoding DNA. This organism represents a basal archaeal lineage and has a highly reduced genome.

引用

页码：12984 / 12988

页数：5

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