Derivatisation reactions in the chromatographic analysis of chemical warfare agents and their degradation products

被引：200

作者：

Black, RM ^{[1
]}

Muir, B ^{[1
]}

机构：

[1] Dstl Porton Down, Salisbury SP4 0JQ, Wilts, England

来源：

JOURNAL OF CHROMATOGRAPHY A | 2003年 / 1000卷 / 1-2期

关键词：

reviews; derivatization; GC; LC; mass spectrometry; chemical warfare agents;

D O I：

10.1016/S0021-9673(03)00183-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of chemical warfare agents and their degradation products is an important component of verification of compliance with the Chemical Weapons Convention. Gas and liquid chromatography, particularly combined with mass spectrometry, are the major techniques used to detect and identify chemicals of concern to the Convention. The more polar analytes, and some of the more reactive or highly volatile agents, are usually derivatised to facilitate chromatography, and to impart properties beneficial for detection. This review focuses on derivatisation reactions used in the chromatographic analysis of chemical warfare agents, their degradation products and metabolites. Crown Copyright (C) 2003 Published by Elsevier Science B.V. All rights reserved.

引用

页码：253 / 281

页数：29