Four pathways of CD1 antigen presentation to T cells

被引：39

作者：

Moody, D. Branch ^{[1
]}

Cotton, Rachel N. ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Rheumatol Immunol & Allergy, 60 Fenwood Rd, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2017年 / 46卷

关键词：

CRYSTAL-STRUCTURE; CYTOPLASMIC TAIL; LIPID ANTIGENS; NKT CELLS; PRESENTING CELLS; BINDING GROOVE; RECOGNITION; MOLECULES; TRAFFICKING; ANGSTROM;

D O I：

10.1016/j.coi.2017.07.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors. This review discusses the intersection of CD1 trafficking and lipid antigen loading mechanisms in cells, highlighting key controversies relating to CD1 gene expression, size mismatches between antigens and CD1 binding clefts and unexpected mechanisms of T cell receptor-based recognition.

引用

页码：127 / 133

页数：7

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