Four pathways of CD1 antigen presentation to T cells

被引：37
作者：
Moody, D. Branch [1 ]
Cotton, Rachel N. [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Rheumatol Immunol & Allergy, 60 Fenwood Rd, Boston, MA 02115 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2017年 / 46卷
关键词：
CRYSTAL-STRUCTURE; CYTOPLASMIC TAIL; LIPID ANTIGENS; NKT CELLS; PRESENTING CELLS; BINDING GROOVE; RECOGNITION; MOLECULES; TRAFFICKING; ANGSTROM;
D O I：
10.1016/j.coi.2017.07.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors. This review discusses the intersection of CD1 trafficking and lipid antigen loading mechanisms in cells, highlighting key controversies relating to CD1 gene expression, size mismatches between antigens and CD1 binding clefts and unexpected mechanisms of T cell receptor-based recognition.
引用
收藏
页码：127 / 133
页数：7
相关论文
共 60 条
  • [1] Cellular mechanisms governing cross-presentation of exogenous antigens
    Ackerman, AL
    Cresswell, P
    [J]. NATURE IMMUNOLOGY, 2004, 5 (07) : 678 - 684
  • [2] CD1a and MHC class I follow a similar endocytic recycling pathway
    Barral, Duarte C.
    Cavallari, Marco
    McCormick, Peter J.
    Garg, Salil
    Magee, Anthony I.
    Bonifacino, Juan S.
    De Libero, Gennaro
    Brenner, Michael B.
    [J]. TRAFFIC, 2008, 9 (09) : 1446 - 1457
  • [3] Batuwangala T, 2003, J IMMUNOL, P2382
  • [4] αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands
    Birkinshaw, Richard W.
    Pellicci, Daniel G.
    Cheng, Tan-Yun
    Keller, Andrew N.
    Sandoval-Romero, Maria
    Gras, Stephanie
    de Jong, Annemieke
    Uldrich, Adam P.
    Moody, D. Branch
    Godfrey, Dale I.
    Rossjohn, Jamie
    [J]. NATURE IMMUNOLOGY, 2015, 16 (03) : 258 - U215
  • [5] CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor
    Borg, Natalie A.
    Wun, Kwok S.
    Kjer-Nielsen, Lars
    Wilce, Matthew C. J.
    Pellicci, Daniel G.
    Koh, Ruide
    Besra, Gurdyal S.
    Bharadwaj, Mandvi
    Godfrey, Dale I.
    McCluskey, James
    Rossjohn, Jamie
    [J]. NATURE, 2007, 448 (7149) : 44 - 49
  • [6] Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens
    Briken, V
    Jackman, RM
    Watts, GFM
    Rogers, RA
    Porcelli, SA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) : 281 - 287
  • [7] Intracellular trafficking pathway of newly synthesized CD1b molecules
    Briken, V
    Jackman, RM
    Dasgupta, S
    Hoening, S
    Porcelli, SA
    [J]. EMBO JOURNAL, 2002, 21 (04) : 825 - 834
  • [8] 2 CLASSES OF CD1 GENES
    CALABI, F
    JARVIS, JM
    MARTIN, L
    MILSTEIN, C
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (02) : 285 - 292
  • [9] Role of lipid trimming and CD1 groove size in cellular antigen presentation
    Cheng, Tan-Yun
    Relloso, Miguel
    Van Rhijn, Ildiko
    Young, David C.
    Besra, Gurdyal S.
    Briken, Volker
    Zajonc, Dirk M.
    Wilson, Ian A.
    Porcelli, Steven
    Moody, D. Branch
    [J]. EMBO JOURNAL, 2006, 25 (13) : 2989 - 2999
  • [10] Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
    Chow, A
    Toomre, D
    Garrett, W
    Mellman, I
    [J]. NATURE, 2002, 418 (6901) : 988 - 994
123456