The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model

被引：12

作者：

McCarthy, Hannah ^{[1
]}

Waters, Elaine M. ^{[2
]}

Bose, Jeffrey L. ^{[2
]}

Foster, Simon ^{[3
]}

Bayles, Kenneth W. ^{[2
]}

O'Neill, Eoghan ^{[4
]}

Fey, Paul D. ^{[2
]}

O'Gara, James P. ^{[1
]}

机构：

[1] Natl Univ Ireland, Dept Microbiol, Sch Nat Sci, Galway, Ireland

[2] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Ctr Staphylococcal Res, Omaha, NE 68198 USA

[3] Univ Sheffield, Krebs Inst, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England

[4] Connolly Hosp, Dept Clin Microbiol, Royal Coll Surg Ireland, Dublin 15, Ireland

来源：

FEMS MICROBIOLOGY LETTERS | 2016年 / 363卷 / 09期

关键词：

Staphylococcus; Autolysin; biofilm; device infection; POLYSACCHARIDE INTERCELLULAR ADHESIN; FIBRONECTIN-BINDING PROTEINS; BIOFILM FORMATION; MOLECULAR CHARACTERIZATION; EPIDERMIDIS; ATL; PATHOGENESIS; EXPRESSION; PREVENTION; MECHANISM;

D O I：

10.1093/femsle/fnw087

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The major Staphylococcus aureus autolysin, Atl, has been implicated in attachment to surfaces and release of extracellular DNA during biofilm formation under laboratory conditions. Consistent with this, polyclonal antibodies to the amidase and glucosaminidase domains of Atl inhibited in vitro biofilm formation. However, in a murine model of device-related infection the community-associated S. aureus strain USA300 LAC JE2 established a successful infection in the absence of atl. These data indicate that Atl activity is not required for biofilm production in this infection model and reveal the importance of characterizing the contribution of biofilm phenotypes to virulence under in vivo conditions.

引用

页数：8

共 2 条

[1] Impact of Staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 strain LAC on virulence in a murine bacteremia model
Rom, Joseph S.
Atwood, Danielle N.
Beenken, Karen E.
Meeker, Daniel G.
Loughran, Allister J.
Spencer, Horace J.
Lantz, Tamara L.
Smeltzer, Mark S.
VIRULENCE, 2017, 8 (08) : 1776 - 1790
[2] Nitrate Reductase NarGHJI Modulates Virulence via Regulation of agr Expression in Methicillin-Resistant Staphylococcus aureus Strain USA300 LAC
Li, Yujie
Pan, Ting
Cao, Ruobing
Li, Wei
He, Zhien
Sun, Baolin
MICROBIOLOGY SPECTRUM, 2023, 11 (03)

← 1 →