Reactions with hydrazonoyl halides 53:: 1Synthesis and antimicrobial activity of triazolino[4,3-a]pyrimidines and 5-arylazothiazoles

被引:16
作者
Abdelhamid, Abdou O. [1 ]
Ismail, Zeineb H.
El Gendy, Marwa S.
Ghorab, Moustafa M.
机构
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12316, Egypt
[2] Al Azhar Univ, Fac Sci, Dept Chem, Girls Branch, Cairo, Egypt
[3] Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Nasr City, Cairo, Egypt
关键词
2,3-Dihydro-1,3,4-thiadiazoles; arylazothiazoles; hydrazonoyl halides; pyrazolines; triazolino[4,3-alpha]pyrimidines;
D O I
10.1080/10426500701501292
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
6-(2-Naphtyl)-1-phenyl-4-3,5-disubstituted-4,3a-triazolino[4,3-a] pyrimidines, [2( 1-(2-naphthyl)-5-substitued (1-pyrazolin-3yl)-4-phenyl(thiazol-5-yl)phenyldiazine and 1-(2-aza-2-{[4-phenyldiazenyl)-(1,3-thiazol-2-yl)]amino}vinyl)-naphthalene-2-ol were synthesized via reactions of hydrazonoyl halides with 4-(2-naphthyl)6- substituted 3,4- dihydropyrimidine-2-thione, Amino(3-(2-naphthyl)-5-substituted pyrazolin-2-ylmethane-1-thione, and 2-hydroxynaphthalenecarbaldehyde-thiosemicarbazone. All structures of the newly synthesized compounds were elucidated by elemental analysis, spectral data, and alternative synthesis methods whenever possible. Some of the new compounds were tested towards bacteria. In general, all tested compounds were capable of highly inhibiting the growth of gram positive of bacteria and gram negative.
引用
收藏
页码:2409 / 2418
页数:10
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