Cancer stem cells From characterization to therapeutic implications

被引：0

作者：

Alajez, Nehad M. ^{[1
]}

机构：

[1] King Saud Univ, Coll Med, Dept Anat, Stem Cell Unit, Riyadh 11461, Saudi Arabia

来源：

SAUDI MEDICAL JOURNAL | 2011年 / 32卷 / 12期

关键词：

TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; GENE-EXPRESSION; SELF-RENEWAL; PROSPECTIVE IDENTIFICATION; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; PANCREATIC-CANCER; MELANOMA-CELLS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cancer stem cell (CSC), or alternatively referred to as the tumor initiating cell (TIC) model, proposes that human cancers are organized in a hierarchical structure with the CSC at the apex. Cancer stem cells are functionally defined by their ability to self-renew, and to recapitulate the hierarchy of the original tumor from which they were derived. Emerging data from the literature suggest that CSCs might be the fraction within the tumor that resists conventional therapies; hence, the CSC paradigm provides new insight into tumor progression and relapse. Herein, we provide literature review of the CSC model, with emphasis on the translational and clinical implications of this model.

引用

页码：1229 / 1234

页数：6

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