Preparation and antibacterial properties of chitosan/polyvinyl alcohol nanofibrous mats using different organic acids as solvents

被引：10
|
作者：
Chen, Lele [1 ,2 ]
Liu, Zhao [3 ]
Shi, Jipeng [1 ,2 ]
Wang, Chengbo [4 ,5 ]
Ding, Ling [1 ,2 ]
Ding, Xu [1 ,2 ]
Teng, Guixiang [1 ,2 ]
Wu, Jianping [1 ,2 ]
Zhang, Ji [1 ,2 ]
机构：
[1] Northwest Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China
[2] Northwest Normal Univ, Inst New Rural Dev, Lanzhou 730070, Peoples R China
[3] Soochow Univ, Affiliated Hosp 1, Orthopaed Inst, Dept Orthopaed Surg, Suzhou 215006, Peoples R China
[4] Chinese Acad Sci, Lanzhou Inst Chem Phys LICP, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China
[5] Chinese Acad Sci, Lanzhou Inst Chem Phys LICP, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China
来源：
PROCESS BIOCHEMISTRY | 2022年 / 122卷
基金：
中国国家自然科学基金;
关键词：
Antibacterial; Chitosan; Polyvinyl alcohol; Organic acid; Electrospinning; MECHANICAL-PROPERTIES; CITRIC-ACID; ACETIC-ACID; CHITOSAN; FABRICATION; NANOPARTICLES; CHITIN; BLEND; SCAFFOLDS; BEHAVIOR;
D O I：
10.1016/j.procbio.2022.08.025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this paper, three kinds of environmentally friendly chitosan (CS)/polyvinyl alcohol (PVA) nanofibrous mats were prepared by electrospinning using low concentrations of acetic acid (AA), succinic acid (SA) and citric acid (CA) as solvents. For the first time, a systematic study on the effect of different organic acids on the properties of CS/PVA nanofibres was performed, which avoided the disadvantages of the use of strong acids or toxic organic acids as solvents. This study aimed to prepare CS/PVA nanofibrous mats to improve the antibacterial effect and biocompatibility. The results showed that the water stability of the prepared CS/PVA/CA nanofibrous mat was higher than that of pure PVA nanofibre mats, and CS/PVA/CA displayed optimal antibacterial activity and biocompatibility. Therefore, the CS/PVA/CA nanofibrous mat offers great potential for antibacterial applications.
引用
收藏
页码：13 / 28
页数：16
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