Two new megastigmane glycosides, physanosides A and B, from Physalis alkekengi L. var. franchetii, and their effect on NO release in macrophages

被引：44

作者：

Qiu, Li ^{[1
]}

Zhao, Feng ^{[2
]}

Liu, Hongwei ^{[3
]}

Chen, Lixia ^{[1
]}

Jiang, Zhihu ^{[1
]}

Liu, Hongxia ^{[1
]}

Wang, Naili ^{[1
]}

Yao, Xinsheng ^{[1
]}

Qiu, Feng ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Dept Nat Prod Chem, Shenyang 110016, Peoples R China

[2] Yantai Univ, Sch Pharm, Laishan District 264005, Yantai, Peoples R China

[3] Capital Univ Med Sci, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 05期

关键词：

D O I：

10.1002/cbdv.200890072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new megastigmane glycosides, physanosides A and B (I and 2, resp.), were isolated from Physalis alkekengi L. var. franchetii, together with four known compounds (6S,9R)-roseoside (3), (6S,9S)-roseoside (4), (6R,9S)-3-oxo-alpha-ionol beta-D-glucopyranoside (5), and citroside A (6). Their structures were elucidated on the basis of physicochemical evidence, in-depth NMR spectroscopic analysis, high-resolution mass spectrometry, and CD spectroscopy, and their inhibitory effect on NO production was also examined. Compounds 2 and 3 exhibited strong inhibition on lipopolysaccharide-induced NO release by macrophages with IC(50) values of 9.93 and 7.31 mu m, respectively.

引用

页码：758 / 763

页数：6