Design and validation of a multiplexed low coherence interferometry instrument for in vivo clinical measurement of microbicide gel thickness distribution

被引：4

作者：

Drake, Tyler K. ^{[1
]}

DeSoto, Michael G. ^{[1
]}

Peters, Jennifer J. ^{[1
]}

Henderson, Marcus H. ^{[1
]}

Murtha, Amy P. ^{[2
]}

Katz, David F. ^{[1
]}

Wax, Adam ^{[1
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Div Maternal Fetal Med, Dept Obstet & Gynecol, Durham, NC 27710 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 10期

基金：

美国国家卫生研究院;

关键词：

TRANSPORT-THEORY;

D O I：

10.1364/BOE.2.002850

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a multiplexed, Fourier-domain low coherence interferometry (mLCI) instrument for in vivo measurement of intravaginal microbicide gel coating thickness distribution over the surface of the vaginal epithelium. The mLCI instrument uses multiple delivery fibers to acquire depth resolved reflection profiles across large scanned tissue areas. Here mLCI has been adapted into an endoscopic system with a custom imaging module for simultaneous, co-registered measurements with fluorimetric scans of the same surface. The resolution, optical signal-to-noise, and cross-talk of the mLCI instrument are characterized to evaluate performance. Validation measurements of gel thickness are made using a calibration socket. Initial results from a clinical study are presented to show the in vivo capability of the dual-modality system for assessing the distribution of microbicide gel vehicles in the lower human female reproductive tract. (C) 2011 Optical Society of America

引用

页码：2850 / 2858

页数：9

共 12 条

[1] The optimal analysis of MRI data to quantify the distribution of a microbicide [J].