Leucine-rich alpha 2 glycoprotein is a new marker for active disease of tuberculosis

被引:23
|
作者
Fujimoto, Minoru [1 ]
Matsumoto, Tomoshige [2 ,3 ]
Serada, Satoshi [1 ]
Tsujimura, Yusuke [4 ]
Hashimoto, Shoji [5 ]
Yasutomi, Yasuhiro [4 ]
Naka, Tetsuji [1 ,6 ]
机构
[1] Kochi Univ, Kochi Med Sch, Dept Clin Immunol, Nankoku, Kochi 7838505, Japan
[2] Osaka Prefectural Hosp Org, Dept Med, Osaka Habikino Med Ctr, Habikino 5838588, Japan
[3] Osaka AntiTB Assoc, Dept Internal Med, Osaka Hosp, Neyagawa, Osaka 5720854, Japan
[4] Natl Inst Biomed Innovat Hlth & Nutr, Tsukuba Primate Res Ctr, Lab Immunoregulat & Vaccine Res, Tsukuba, Ibaraki 3050843, Japan
[5] Osaka Prefectural Hosp Org, Dept Clin Res Ctr, Osaka Habikino Med Ctr, Habikino 5838588, Japan
[6] Natl Inst Biomed Innovat Hlth & Nutr, Lab Immune Signal, Ibaraki 5670085, Japan
关键词
BIOMARKER; ALPHA-2-GLYCOPROTEIN; ALPHA(2)-GLYCOPROTEIN; THERAPY; PROTEIN; LRG1;
D O I
10.1038/s41598-020-60450-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a global health problem. At present, prior exposure to Mtb can be determined by blood-based interferon-gamma release assay (IGRA), but active TB is not always detectable by blood tests such as CRP and ESR. This study was undertaken to investigate whether leucine-rich alpha-2 glycoprotein (LRG), a new inflammatory biomarker, could be used to assess active disease of TB. Cynomolgus macaques pretreated with or without Bacille Calmette-Guerin (BCG) vaccination were inoculated with Mtb to induce active TB. Blood was collected over time from these animals and levels of LRG as well as CRP and ESR were quantified. In the macaques without BCG vaccination, Mtb inoculation caused extensive TB and significantly increased plasma CRP and LRG levels, but not ESR. In the macaques with BCG vaccination, whereas Mtb challenge caused pulmonary TB, only LRG levels were significantly elevated. By immunohistochemical analysis of the lung, LRG was visualized in epithelioid cells and giant cells of the granulation tissue. In humans, serum LRG levels in TB patients were significantly higher than those in healthy controls and declined one month after anti-tubercular therapy. These findings suggest that LRG is a promising biomarker when performed following IGRA for the detection of active TB.
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页数:10
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