Enantioselective Rhodium(I)-Catalyzed [3+2] Annulations of Aromatic Ketimines Induced by Directed C?H Activations

被引：166

作者：

Tran, Duc N. ^{[1
,2
]}

Cramer, Nicolai ^{[1
]}

机构：

[1] EPFL SB ISIC LCSA, Lab Asymmetr Catalysis & Synth, CH-1015 Lausanne, Switzerland

[2] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 47期

基金：

欧洲研究理事会;

关键词：

alkynes; annulation; asymmetric catalysis; C?H activation; rhodium; H BOND ACTIVATION; CATALYZED DIRECT ARYLATION; ORGANIC-SYNTHESIS; CARBON-HYDROGEN; INTERMOLECULAR HYDROACYLATION; REGIOSELECTIVE SYNTHESIS; BENZOIC-ACIDS; ALKYNES; FUNCTIONALIZATION; CLEAVAGE;

D O I：

10.1002/anie.201105766

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triple selectivity: Highly substituted indenylamines can be obtained with high enantioselectivity by formal [3+2] additions of aryl ketimines with internal alkynes. These rhodium(I)-catalyzed processes proceed by selective C-H activation of one of the two arene substituents, regioselective carbometalation of the alkyne, and enantioselective addition across the imine. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11098 / 11102

页数：5

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