Fast Bound Pool Fraction Mapping Using Stimulated Echoes

Magnetization transfer imaging advanced to an indispensible tool for investigating white matter changes. Quantitative magnetization transfer imaging methods allow the determination of the bound pool fraction (BPF), which is thought to be directly linked to myelin integrity. Long acquisition times and high specific absorption rates are still inhibiting broad in vivo utilization of currently available BPF mapping techniques. Herewith, a stimulated echoes amplitude modulation-based, single-shot echo planar imaging technique for BPF and T(1) quantification is presented at 3T. It allows whole brain mapping in 10-15 min and is low in specific absorption rates. The method was validated with different concentrations of bovine serum albumin (BSA) phantoms. Infra- and inter-subject variability was assessed in vivo. Phantom measurements verified linearity between bovine serum albumin concentrations and measured BPF, which was independent of T(1) variations. T(1) values in the phantoms correlated well with values provided by standard T(1) mapping methods. Intrasubject variability was minimal and mean regional BPFs of 10 volunteers (e.g., left frontal white matter = 0.135 +/- 0.003, right frontal white matter = 0.129 +/- 0.006) were in line with previously published data. Assessment of interhemispheric BPF differences revealed significantly higher BPF for the left brain hemisphere. To sum up, these results suggest the proposed method useful for crosssectional and longitudinal studies of white matter changes in the human brain. Magn Reson Med 66:717-724, 2011. (C)2011 Wiley-Liss, Inc.