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Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia
被引:6
作者:
Dogan, Yasar
[1
]
Erkan, Tulay
[1
]
Onal, Zerrin
[1
]
Usta, Merve
[1
]
Dogusoy, Gulen
[2
]
Cokugras, Fugen Cullu
[1
]
Kutlu, Tufan
[1
]
机构:
[1] Istanbul Univ, Div Pediat Gastroenterol Hepatol & Nutr, Dept Pediat, Cerrahpasa Med Fac, TR-23119 Istanbul, Turkey
[2] Istanbul Univ, Dept Med Pathol, Cerrahpasa Med Fac, TR-23119 Istanbul, Turkey
关键词:
IRON-DEFICIENCY ANEMIA;
INFECTION;
CHILDREN;
ERADICATION;
SEROPREVALENCE;
POPULATION;
REVERSAL;
GROWTH;
D O I:
10.1155/2012/214581
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Aim. To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups. Results. The study included 64 cases (average: 10.2 +/- 0.4 years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were 45.5 +/- 4.7% and 1.9 +/- 0.1, respectively. Hp-negative cases showed significantly different values of 17.8 +/- 4.5% and 1.3 +/- 0.2, respectively. Hemoglobin and serum ferritin values of Hp-positive cases were 12.7 +/- 0.2 g/dL and 32.5 +/- 2ng/mL, but these were comparable with Hp-negative cases (12.6 +/- 0.1 g/dL and 30.7 +/- 4.4ng/mL). Conclusions. Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.
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