Polymer-Based Drug Delivery Systems for Cancer Treatment

被引：115

作者：

Guo, Xing ^{[1
]}

Wang, Lin ^{[1
]}

Wei, Xiao ^{[1
]}

Zhou, Shaobing ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2016年 / 54卷 / 22期

基金：

中国国家自然科学基金;

关键词：

amphiphilic polymers; cancer therapy; drug delivery; nanocarriers; stimuli-responsive; AMPHIPHILIC BLOCK-COPOLYMER; CRITICAL SOLUTION TEMPERATURES; POLYION COMPLEX MICELLES; CROSS-LINKED MICELLES; TARGETED INTRACELLULAR DELIVERY; CHARGE-REVERSAL NANOPARTICLES; HYALURONIC-ACID NANOPARTICLES; ANTICANCER DRUG; IN-VIVO; BREAST-CANCER;

D O I：

10.1002/pola.28252

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This review is focused on the chemical design and synthesis of polymer-based drug delivery systems, in particular with stimuli-responsive nanoplatforms for cancer treatment. We provide a brief description of the properties, synthesis and advantages of amphiphilic block copolymers, including polyether-polyester and polyether-polyanhydride. As for stimuli-responsive polymers, we detail the recent innovative techniques for constructing smarter, more precise and optimally tuned nanocarriers that release drug in the disease site. This review is presented in the context of polymer science research, with special attention focused on the tailor-made polymers containing specific chemical functionalities. (C) 2016 Wiley Periodicals, Inc.

引用

页码：3525 / 3550

页数：26

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