Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development

被引：12

作者：

Goel, Bharat ^{[1
]}

Dey, Biswajit ^{[2
]}

Chatterjee, Essha ^{[2
]}

Tripathi, Nancy ^{[1
]}

Bhardwaj, Nivedita ^{[1
]}

Kumar, Sanjay ^{[1
]}

Guru, Santosh Kumar ^{[2
]}

Jain, Shreyans K. ^{[1
]}

机构：

[1] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India

[2] Natl Inst Pharmaceut Educ & Res NIPER, Dept Biol Sci, Hyderabad 500037, Telangana, India

来源：

ACS OMEGA | 2022年 / 7卷 / 33期

关键词：

COLCHICINE DERIVATIVES; SUPERBA; DESIGN; TUBULIN;

D O I：

10.1021/acsomega.2c02688

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gloriosine, a colchicine-like natural product, is widely obtained from Gloriosa superba roots. Despite having remarkable anticancer potential, colchicine could not pave its way to the clinic, while gloriosine is yet to be investigated for its pharmacological effects. In the present work, 14 compounds, including gloriosine, were isolated from the G. superba roots and were characterized by NMR spectroscopy. Gloriosine (11) was evaluated for its antiproliferative activity against a panel of 15 human cancer cell lines of different tissues and normal breast cells. Gloroisine (11) displayed significant antiproliferative activity against various cancer cell lines selectively, with IC50 values ranging from 32.61 to 100.28 nM. Further, gloriosine (11) was investigated for its apoptosis-inducing ability and found to form apoptotic bodies. It also inhibited A549 cell migration in the wound healing assay. Finally, molecular docking studies were performed to explore the possible binding modes of gloriosine with the colchicine-binding site of tubulin protein. Our findings suggested that gloriosine might be a potential lead for anticancer drug discovery.

引用

页码：28994 / 29001

页数：8

共 37 条

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