Albumin protects cultured cerebellar granule neurons against zinc neurotoxicity

被引：7
|
作者：
Lin, SZ [1 ]
Tagliabracci, VS [1 ]
Chen, XM [1 ]
Du, YS [1 ]
机构：
[1] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
来源：
NEUROREPORT | 2005年 / 16卷 / 13期
关键词：
albumin; neuronal death; neuroprotection; zinc;
D O I：
10.1097/01.wnr.0000176523.34594.98
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we have investigated the role of albumin in zinc-induced neurotoxicity of cultured rat cerebellar granule neurons. ZnCl2 induces cerebellar granule cell death in a time- and concentration-dependent manner and albumin in serum affords a significant protection against zinc-induced neurotoxicity. We further measured intracellular zinc concentrations in the presence or absence of albumin. The results showed that exogenously added ZnCl2 induced an increase in intracellular zinc concentrations in a concentration-dependent fashion in albumin-free buffer. However, in the presence of albumin, it dramatically decreased ZnCl2-induced elevation of intracellular zinc concentrations. These results indicate that albumin protects against zinc-induced neurotoxicity by blocking extracellular zinc uptake by neurons.
引用
收藏
页码：1461 / 1465
页数：5
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